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PB-22 and 5F-PB-22 had been the very first synthetic cannabinoids to include a quinoline substructure and an ester linkage. These website compounds are thought to have been synthesized Using the intention of constructing a synthetic cannabinoid prodrug, which might boost absorption and confound detection. Ester bonds are simply biodegradable by way of spontaneous or endogenous, nonspecific esterase hydrolysis, which has been generally used in medicinal chemistry to create ester prodrugs.
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